A New Inherited Abnormality of Hemoglobin and Its Interaction with Sickle Cell Hemoglobin

A new inherited abnormality of hemoglobin and its interaction with sickle cell hemoglobin.

V. NEEL, M.D., PH.D. T HIS REPORT deals with a new inherited abnormality of hemoglobin encountered in American Negroes. The existence of this traitcame to light ill the course of extensive clinical and genetic studies u’egarding the sickling pheuiomenon. Among the individuals examined thei’e were anumber of patients ‘it-h a hemolytic syndrome associated with erythrocytic sickling in whom neithe...

Red cell life span in sickle cell-hemoglobin C disease with a note about sickle cell-hemoglobin O ARAB.

Red cell survival was measured in ten subjects with S-C disease and one with S-O Arab (alpha 2 beta 2-121 glu yields lys) disease using both DF32p and 51Cr as tags. Red cell volume was slightly reduced in most patients (87% plus or minus 20% of predicted normal). In nine SC patients, mean red cell life (DF32p) was 28.9 plus or minus 4.0 days. For one SC subject it was significantly longer (47.9...

Intraerythrocytic Hemoglobin Crystals in Sickle Cell-hemoglobin C Disease.

Hemoglobin I: an inherited hemoglobin anomaly.

By D. L. RUCKNAGEL, E. B. PAGE AND W. N. JENSEN S TUDIES OF HEMOGLOBIN by the various technics of electrophoresis aud alkali denaturatiomi have resulted imi a strikimig development in the knowledge of abnormal hemoglobins amid in the hereditary hemolytic amieniias, some of them never previously recognized. During the course of the examination of the electrophoretic properties of the hemoglobimi...

Hemoglobin I: An Inherited Hemoglobin Anomaly

By D. L. RUCKNAGEL, E. B. PAGE AND W. N. JENSEN S TUDIES OF HEMOGLOBIN by the various technics of electrophoresis aud alkali denaturatiomi have resulted imi a strikimig development in the knowledge of abnormal hemoglobins amid in the hereditary hemolytic amieniias, some of them never previously recognized. During the course of the examination of the electrophoretic properties of the hemoglobimi...